A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
New-onset dermatomyositis following SARS-CoV-2 infection and vaccination: a case-based reviewArticle Published on 2022-12-012022-11-15 Journal: Rheumatology International [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Affect antibodies antibody association autoantibody Autoimmune disease COVID-19 COVID-19 vaccines Defense dermatomyositis Immunosuppressive treatment increase in Infection Intensive Interaction internal organ MDA5 mRNA vaccines occurred pandemic Patient patients positive pulmonary system reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Seven systematic review the SARS-CoV-2 type I vaccination Viral RNA [DOI] 10.1007/s00296-022-05176-3 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay qPCR. remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
Correlation between Type I Interferon Associated Factors and COVID-19 SeverityArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome Adaptive immune response Affect Antiviral antiviral response caused cells Chronic diseases conditions coronavirus COVID-19 COVID-19 severity declined dendritic cell dysfunction dysregulation early phase Factor Factors Frequency IFN IFN response IFN signature increased risk individual individual immune response inhibit magnitude Mild no symptoms Patient plasmacytoid dendritic cell plasmacytoid dendritic cell 1 Prevent produced producing promote response responsible risk risk factor SARS-CoV-2 severe coronavirus disease severe COVID-19 tissue damage Type type I Type I IFN type I IFNs type I interferon type I interferon. viral infection viral infections viral replication viruses [DOI] 10.3390/ijms231810968 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
Distinct type I interferon responses between younger women and older men contribute to the variability of COVID-19 outcomes: Hypothesis generating insights from COVID-19 convalescent individuals젊은 여성과 나이든 남성 사이의 뚜렷한 유형 I 인터페론 반응은 COVID-19 결과의 가변성에 기여합니다: COVID-19 회복기 개인으로부터 통찰력을 생성하는 가설Article Published on 2022-09-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] age Analysis blood type C-reactive protein calculated Clinical outcome contribute convalescent convalescent individual convalescent individuals COVID-19 COVID-19 infected patients determined by ELISA epidemiological studies exhibited female females groups healthy individual highest Hospitalization hospitalized patients Ifi44 IFN IFN-inducible gene IFN-inducible genes IL-6 IL-6 level Inclusion infected patients interleukin less lowest male Male sex males median men Mortality Older opposite outcome PCR Peripheral blood population groups premenopausal female quantified real time real time PCR response SARS-CoV-2 serum Serum level serum levels Sex shown significantly significantly higher significantly increased Stratification Type type I Type I IFN type I interferon type I interferon (IFN). Variability was performed women [DOI] 10.1016/j.cyto.2022.155964 PMC 바로가기 [Article Type] Article
Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3 Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 진단, [키워드] atomic binding cleavage Complete complex CRISPR Degradation degrade detect DNA DNA degradation double-stranded dsDNA dynamic elicit Escherichia coli exhibit Genome in vitro mechanism Microscopy multi non-specific NTS nucleic acid PAM Partial priming Protein R-loop recruited Release sequence single-stranded DNA spacer ssDNA Type type I [DOI] 10.1038/s41467-022-32618-0 [Article Type] Research
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activityResearch article Published on 2022-08-242022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique [DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article